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Postdoctoral Research Associate  (posted January 9, 2018)

Rozalyn Anderson Laboratory, Metabolism of Aging Program, University of Wisconsin-Madison

Position Summary: A fully funded postdoctoral position is available in the Anderson Laboratory at the University of Wisconsin-Madison to conduct research focused on the basic biological mechanisms of aging. The overall goal of the work is to examine how aging increases disease vulnerability at the molecular level. In particular, the laboratory uses caloric restriction and genetic mouse models to examine the mechanisms through which metabolism impinges on the aging process. The successful candidate will design and implement strategies for investigating the mechanisms connecting metabolism, caloric restriction, and aging. The candidate is also expected to explore new avenues and seek independent funding as part of their own career development. Principal duties: Assist in the execution of ongoing projects performing experiments in accordance with the goals of the Metabolism of Aging Program. Compile and analyze experimental results, prepare illustrations and data elements, contribute text and background research for manuscripts, and assist with publication in scholarly journals.  Develop new avenues of research both as part of the Anderson research program and in anticipation of transition to independent career, work both individually and collaboratively with principal investigator, collaborators, and other lab members to pursue shared and independent funding opportunities, and provide mentoring to graduate/undergraduate students and instruction in laboratory techniques. Participation at research meetings and academic conferences will also be expected, including oral and poster presentations. Prepare content for grant applications, and ensure compliance with laboratory rules and safety.

Qualifications: Applicants should possess a Ph.D. in biochemistry, molecular and/or cellular biology or a closely related field. Significant experience in cell and molecular biology is absolutely required, including cell culture of immortalized and primary lines, transfection, generation of stable lines, and cellular differentiation. Strong background in cellular & molecular biology techniques (IP, IF, ChIP, mutagenesis, cloning etc.) expected. The preferred applicant will also have experience handling molecular profiling data (transcriptome, proteome, etc.) sets. The candidate must have a proven academic publication track record, including first-author publications. Previous experience instructing and/or mentoring undergraduate and graduate students is a plus.

To apply: Email a CV, with contact info for three references, to rozalyn.anderson@wisc.edu

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The Lamming Laboratory for the Molecular Physiology of Aging at the University of Wisconsin-Madison is recruiting a highly motivated new/recent graduate (Ph.D. or M.D.) who wishes to develop an independent research career. Dr. Lamming is focused on understanding how nutrient-responsive signaling pathways can be harnessed to promote health and longevity. Currently, research in the Lamming Laboratory has two major focuses: 1) Determining how specific macronutrients - particular the branched-chain amino acids leucine, isoleucine, and valine - influence lifespan and healthspan in wild-type mice, mouse models of age-related diseases, including type 2 diabetes, cancer, and Hutchinson-Gilford Progeria Syndrome, and in humans; 2) Determining the physiological and molecular mechanisms that explain how the insulin/IGF-1/mTOR signaling pathway and the mTOR inhibitor rapamycin control health and longevity. More information about our research and publications can be found at lamminglab.org. Interested candidates with Ph.D. and/or M.D. are encouraged to apply. Experience with cell culture, molecular biology, immunohistochemistry, and mice preferred but not required. An individual training plan will designed to meet the candidate's expertise, research interests and career goals. Specific duties will include identifying research problems and designing research methodologies; assist in the writing of grants and manuscripts for peer-reviewed journals; and additional duties as requested by the principal investigator. The successful applicant must have excellent scientific, organizational, record-keeping, and problem-solving skills.

To apply: Email a CV, with contact info for three references, to dlamming@medicine.wisc.edu

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