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Staff Scientist/Post-Doctoral Fellow – Metabolomics
Aging and Metabolism
Tim Griffin, Ph.D.
The Oklahoma Medical Research Foundation (OMRF) is seeking a staff scientist or post-doctoral fellow interested in collaborative team-based research to direct metabolomics studies within a newly created Metabolic Phenotyping Core. This position is based within the Aging and Metabolism Research Program at OMRF. Primary responsibilities include the maintenance, operation, and analysis of metabolomic data generated from Agilent instruments, including a high-resolution LC-MS/MS instrument (UHPLC-qTOF 1290 Infinity II-6546) acquired in 2020 and a GC-MS instrument (7890B GC, 5977A Extractor XL MSD) acquired in 2015. The successful candidate must have hands-on metabolomics mass spectrometry experience in biomedical research, with a preference for LC-MS-based metabolomics. Prior proteomic mass spectrometry expertise will be considered. Experience conducting stable-isotope metabolic flux analyses is preferred but not required. The position requires excellent verbal and written communication skills and the ability to work both independently and as part of a team. Prior collaborative and/or service-related experience is preferred, including familiarity with Agilent MassHunter software, open-source metabolomics software, and statistics. The selected candidate will contribute to the success of the Center for Cellular Metabolism Research in Oklahoma, which is a Phase I NIH COBRE proposal with the goal of cultivating novel multidisciplinary research focusing on metabolism. Thus, the research interactions will include a multi-disciplinary group of colleagues at OMRF as well as at the neighboring University of Oklahoma Health Sciences Center.
Faculty in the Aging and Metabolism Research Program are committed to providing Staff Scientists opportunities for career advancement, and Post-doctoral Fellows also receive significant support to successfully transition to independent research careers. The position is available immediately.
OMRF (omrf.org) is an independent, nonprofit biomedical research institute located adjacent to the campus of the University of Oklahoma Health Sciences Center (OUHSC) in Oklahoma City. OMRF and OUHSC also house the National Institute on Aging-funded Oklahoma Nathan Shock Center that provides unique research cores to support age–related research (http://aging.ouhsc.edu/). Oklahoma City offers a dynamic and flourishing downtown area, with low cost of living, short commute times and a diversified economy.
OMRF’s excellence can only be fully realized by individuals who share our commitment to diversity, equity and inclusion. Successful candidates will demonstrate commitment to these values. OMRF is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to gender, sexual orientation, gender identity, race, color, national origin, age, religion, disability, veteran status or any other legally protected characteristic.
Minimum Qualifications: Ph.D., M.D., or comparable doctoral degree at the time of the appointment. At least one year of hands-on experience in metabolomics research.
Interested persons should send 1) a current CV, 2) a letter of interest, and 3) names and contact information of three professional references via email to: Tim Griffin, Ph.D., [Tim-Griffin@omrf.org]
Apply online at http://omrf.peopleadmin.com/postings/3877
Job Title: Postdoctoral Associate (Tumor Initiation and Maintenance) Adams Lab
Dr. Peter D. Adams’ lab investigates the impact of chromatin and epigenetics on cellular senescence, aging, and cancer. In particular, the lab hypothesizes that age-associated changes in chromatin and epigenetic programming contribute to the dramatic age-associated increase in the incidence of cancer. While age is the biggest single risk factor for most cancers, the reason for this is currently poorly understood. For more information about the lab, please go to: http://padamslab.org/ or email Peter Adams email@example.com
The lab strives to be highly collaborative with other labs in San Diego, the US, and elsewhere, for example collaborating with computational biologists, immunologists, experts in specific mouse models of cancer and aging, and surgeons, pathologists, and clinical oncologists.
The Adams laboratory has a Postdoctoral Associate position available. Applications are invited from ambitious, independent, and motivated candidates to join the lab of Professor Adams investigating the epigenetics of aging and cancer. The specific project in the broad epigenetics-cancer-aging area can be discussed, but possible projects include: 1) investigating age-dependent epigenetic changes that lead to increased incidence of cancer with age; 2) mechanism of formation of pro-inflammatory “cytoplasmic chromatin fragments (CCF)” (activators of cGAS/STING pathway) in senescent cells; 3) mechanisms and consequence of DNA methylation clocks; 4) defining mechanisms of chromatin homeostasis (“chromostasis”) that facilitate epigenetic and phenotypic stability and healthy aging; and 5) epigenetic dysregulation in Acute Myeloid Leukemia that can be exploited for the development of novel therapies.
TO APPLY: Interested candidates should apply online to the SBP career site by submitting one PDF document with a cover letter, CV, references and list of any publications or accomplishments.
Knowledge, Skills and/or Abilities
The Scientists at Sanford Burnham Prebys Medical Discovery Institute are making research breakthroughs in cancer, neuroscience, immunology, and children's disease. We are also at the forefront of finding solutions for emerging health threats such as COVID-19, where we are working to identify drugs that may help millions of people. During our more than 40 year history, we have established an NCI-designated Cancer Center, designed one of the most sophisticated drug discovery centers in the nonprofit world, and created global collaborations that are leading to preventions, treatments and cures to improve human health.
Sanford Burnham Prebys Medical Discovery Institute is an Equal Opportunity employer – M/F/Veteran/Disability – committed to the hiring, advancement and fair treatment of all individuals. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, or any other protected status as designated by federal, state or local law. For additional information about your rights as an applicant, click HERE.
Maternal age effects: mitochondrial and epigenetic mechanisms
Marine Biological Laboratory | Woods Hole, MA
A postdoctoral research position is available to study the cellular, genetic, and epigenetic mechanisms of maternal age effects on offspring health and lifespan. The project will focus on the role of mitochondrial dynamics and function in maternal age effects, using molecular, bioinformatic, biochemical, and imaging techniques.
This is an NIH-funded project in the laboratory of Dr. Kristin Gribble at the Marine Biological Laboratory, Woods Hole, MA. The lab researches the mechanisms and evolution of aging and maternal and transgenerational effects on offspring health. We use rotifers as a model system for our work. For more information about the lab’s research and publications, see mbl.edu/jbpc/gribble.
Applicants should possess a Ph.D. in molecular biology, cell biology, biochemistry, genetics, bioinformatics, or a related field. The ideal candidate will have a record of scientific rigor, productivity, and creativity. Excellent oral and written communication skills are required. Knowledge of rotifer biology is not necessary; highly motivated individuals with experience in other model systems and with a background in bioinformatics, cell biology, biochemistry, epigenetics, and/or imaging are encouraged to apply.
Please submit (1) a cover letter with a brief description of your research experience and how you will contribute to research on the mechanisms of maternal effects on offspring, (2) a CV, and (3) contact information for at least three references.
Postdoctoral Position Available
A postdoctoral position is available immediately in the Barshop Institute and the Department of Cellular and Integrative Physiology at the University of Texas Health San Antonio. The applicant will work on mechanisms of pathogenesis of Alzheimer’s disease (AD) and related dementias using rodent models, with a specific focus on the role of tau, mechanisms of aging, and cerebrovascular pathways of AD. For more information please see the laboratory’s website https://www.galvanlab.org
The successful candidate should hold a Ph.D. in neuroscience, biochemistry, genetics, cellular or molecular biology, physiology, or other related fields and have a record of creativity and strong scientific productivity. Working experience on mouse models, optical imaging, primary neuron cell cultures, molecular biology and genetics, and/or a background in brain vascular biology, is strongly preferred, but not exclusively required. Please provide a curriculum vitae, a brief summary of research experience and goals, and the names and contact information of three references to Dr. Veronica Galvan (firstname.lastname@example.org).
Graduate Student Position Advertisement
The Mason Laboratory at Utah State University, School of Veterinary Medicine, Department of Animal, Dairy, and Veterinary Sciences is seeking an outstanding PhD and/or MS student to join our laboratory. This position is jointly supported by the NIH/NIA, the USU School of Veterinary Medicine and the USU Department of Animal, Dairy and Veterinary Sciences.
Research in the Mason lab is broadly focused on elucidating the mechanisms of menopause-associated, ovarian-dependent increase in disease rates. Work in this lab focuses on the surgical and molecular manipulation of ovarian function in mice (including Gene Therapy) to discover the mechanisms underlying the negative physiological consequences of female reproductive senescence. We have previously extended life and health span with our ovarian manipulations. The goal of the current work is to understand the physical and genetic mechanisms that provide the health-protective effects of the ovaries and harness these mechanisms to restore health in post-reproductive females.
The ideal candidate will be highly motivated and creative with an interest in reproductive biology and/or aging biology. The successful candidate should have a background in biology, animal science, biomedical science or related field and must meet the admission requirements for M.S./Ph.D. students set by Utah State University Graduate Studies (https://gradschool.usu.edu/) and the Department of Animal, Dairy and Veterinary Sciences graduate program (https://advs.usu.edu/students/degrees). Applicant experience in rodent handling, viral transduction (rAAV) and histology/pathological analysis are desired, but not required. Preference will be given to candidates that also have some molecular experience (DNA/RNA/protein extraction and analysis) or experience with histology and/or genetic manipulation.
Utah State University is located in Logan, Utah and lies in the beautiful Cache Valley of Northern Utah. Students have access to thousands of acres of public land for backcountry skiing, hiking and fishing. Ten major ski resorts and six national parks, including Yellowstone lie within a short drive of campus.
For more information about the lab, please visit the lab website at https://advs.usu.edu/masonlab/
The ADVS graduate website information can be found at https://advs.usu.edu/students/apply.
Interested candidates should send a cover letter that includes current research interests, CV, and names and contact information of three references, to Dr. Jeffrey Mason (email@example.com).
Utah State University COVID-19 Notice:
All students, faculty and staff are required to wear a mask while on campus, in buildings or when social distancing is not possible in accordance with a temporary policy at this time.
Full Notice of Non-discrimination
In its programs and activities, including in admissions and employment, Utah State University does not discriminate or tolerate discrimination, including harassment, based on race, color, religion, sex, national origin, age, genetic information, sexual orientation, gender identity or expression, disability,
status as a protected veteran, or any other status protected by University policy, Title IX, or any other federal, state, or local law.
The following individuals have been designated to handle inquiries regarding the application of Title IX and its implementing regulations and/or USU’s non-discrimination policies:
Executive Director of the Office of Equity
Alison Adams-Perlac firstname.lastname@example.org
Old Main Rm. 161 435-797-1266
Title IX Coordinator
Hilary Renshaw email@example.com
Old Main Rm. 161 435-797-1266
For further information regarding non-discrimination, please visit https://equity.usu.edu/, or contact: U.S. Department of Education Office of Assistant Secretary for Civil Rights 800-421-3481 OCR@ed.gov U.S. Department of Education Denver Regional Office 303-844-5695 OCR.Denver@ed.gov
Postdoctoral position to study the role of cellular senescence in neurodegenerative diseases
This is a joint position between the Kapahi and Campisi Laboratories. The Kapahi and Campisi laboratories are collaborating to study the role of advanced glycation endproducts (AGEs) in cellular senescence and its impact on Alzheimer's disease. This is being achieved by using an interdisciplinary approach combining genetic, pharmacological, biochemical, and genomic approaches in invertebrate model systems C. elegans, mice, and human samples. The broader significance of this research is to help uncover the role of diet and AGEs in the etiology of age-related human diseases like diabetes and Alzheimer's disease.
The current position involves studying the role of glucose and Advanced Glycation Endproducts (AGEs) in diabetes and neurodegeneration using mice, and IPS derived cells. We propose to examine the mechanisms involved in synthesis and detoxification of Advanced Glycation Endproducts (AGEs) and how they cause cellular damage. Previous background in cellular senescence and mouse genetics will be an advantage but not necessary. The candidate will receive training in specific area(s) of research to progress towards an independent career. For more questions regarding this position, please email Pkapahi@buckinstitute.org or visit https://www.buckinstitute.org/lab/kapahi-lab/
Chaudhuri, J., Bose, N., Gong, J., Hall, D., Rifkind, A., Bhaumik, D., Peiris, T. H., Chamoli, M., Le, C. H., Liu, J., Lithgow, G. J., Ramanathan, A., Xu, X. Z. and Kapahi, P. "A Caenorhabditis elegans Model Elucidates a Conserved Role for TRPA1-Nrf Signaling in Reactive alpha-Dicarbonyl Detoxification." Curr Biol 26, no. 22 (2016): 3014-3025. PMC5135008
Chaudhuri J, Bains Y, Guha S, Kahn A, Hall D, Bose N, Kapahi P, et al. The Role of Advanced Glycation End Products in Aging and Metabolic Diseases: Bridging Association and Causality. Cell Metab. 2018;28(3):337-52. PMCID:PMC6355252
Wiley CD, Liu S, Limbad C, Zawadzka AM, Beck J, Demaria M, Campisi J, and Kapahi P, et al. SILAC Analysis Reveals Increased Secretion of Hemostasis-Related Factors by Senescent Cells. Cell Rep. 2019;28(13):3329-37 e5. PMCID:PMC6907691
Campisi J, Kapahi P, Lithgow GJ, Melov S, Newman JC, Verdin E. From discoveries in ageing research to therapeutics for healthy ageing. Nature. 2019;571(7764):183-92. PMCID:PMC7205183
Laberge RM, Sun Y, Orjalo AV, Patil CK, Freund A, Zhou L, Kapahi P, and Campisi J. MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation. Nat Cell Biol. 2015;17(8):1049-61. PMCID:PMC4691706
The Buck Institute for Age Research is the only independent institute in the U.S. devoted solely to research on aging and age-related diseases. Our mission is to increase the healthspan, the healthy years of life. Awarded a federal grant to establish interdisciplinary research in a new field called Geroscience, Buck scientists work in a unique, collaborative environment that allows scientists to initiate studies quickly and respond to new opportunities. The Buck Institute has excellent in-house proteomic, genomic, and microscopy facilities. Our scientists represent a variety of complementary fields, including genetics, epigenetics, biochemistry, molecular biology, bioenergetics, age-associated disease, and technological disciplines such as genomics, proteomics, protein interaction networks, and bioinformatics. The Buck Institute has an excellent postdoctoral research program. We offer competitive salaries, excellent benefits, a dynamic work environment, and new state-of-the-art facilities. For more information www.buckinstitute.org
CENTER OF EXCELLENCE FOR AGING AND BRAIN REPAIR
University of South Florida | 12901 Bruce B Downs Blvd, | Tampa, FL 33620-4301
Paula C. Bickford, PhD, Distinguished Professor
Post-Doctoral Fellowship available nowSeeking a bright neuroscientist interested in aging and neuroimmunology of Alzheimer’s Disease
Exosomes from Adipose-derived Stem Cells Modulate Age-dependent Progression of Tauopathies: NIH funded postdoctoral positions are available immediately to highly motivated individuals to participate in ongoing studies on Alzheimer's disease (AD). Our laboratory is focusing on the idea that changes in immune function that occur with aging is an important factor to examine when following the progression of Tauopathies associated with Alzheimer’s disease and related disorders. Our lab focuses on examining the complex proteomic and functional phenotype of microglia and how this is affected by aging using mouse models of tauopathies. Furthermore, we have discovered that exosomes derived from adipose derived stem cells are potent modulators of inflammation and have potential to serve as therapeutic interventions in age-related tauopathies.
Flowers A, Bell-Temin H, Jalloh A, Stevens SM, Jr., Bickford PC (2017) Proteomic anaysis of aged microglia: shifts in transcription, bioenergetics, and nutrient response. J Neuroinflammation 14:96.
Patel NA, Moss LD, Lee J-Y, Tajiri N, Acosta S, Hudson C, Parag S, Cooper DR, Borlongan CV, Bickford PC (2018) Long noncoding RNA MALAT1 in exosomes drives regenerative function and modulates inflammation- linked networks following traumatic brain injury. Journal of Neuroinflammation 15:204.
Salary commensurate with experience NIH postdoctoral scale.
These positions are available for up to 2-3 years.
Job Opening Number: 22860 :apply online via USF Jobs or email Dr. Bickford
posted June 6, 2020
Biology of Aging & Age-Related Diseases T32 Traing Grant
About the Grant: The Biology of Aging and Age-Related Disease NIH/NIA training program is led by Dr. Sanjay Asthana and Dr. Rozalyn Anderson at the University of Wisconsin – Madison. Our training program and expert mentoring team covers the spectrum of aging research, from basic mechanisms of aging to biology of age-related disease, and translational studies of preventative interventions and clinical application. This unique grant covers career development for post-doctoral fellows though didactic training in Basic and Translational Aging Biology, mentored training and professional skill development, the Biology of Aging Seminar Series, and support for conference attendance. For more information about our mentors, trainees, program directors, and more please visit: https://biologyofaging.wisc.edu/.
Earliest Start Date: May 1st, 2021
Application Deadline: The position will remain open until filled and candidates will be considered on a first come first served basis.
Apply: Submit the following to firstname.lastname@example.org
Sara Seton (formerly Wray)
T32 Program Coordinator
Phone: (608) 265-5147
We invite you to join us as a graduate student (Ph.D. or M.D.-Ph.D.) or postdoctoral fellow to study the biology of aging at the world-renowned Barshop Institute. We are the only institution in the US to house both a Nathan Shock Center on the Biology of Aging, which is a grant from the National Institute on Aging that supports basic aging research, as well as an Older Americans Independence Center (often called “Pepper Center”), a grant from the NIA to support translational aging research. We have more than 100 faculty members engaged in various aspects of aging research. Our NIA-funded Training Grant has 4 predoctoral graduate student positions and 4 postdoctoral fellowships available.
This training program for research scientists covers such areas as the genetics of aging, lifespan, and intervention analyses in aging and models of age-related diseases. Focus is on translational-oriented trials in a wide range of animal models, including marmosets, and early-phase clinical studies in human subjects. Trainees will participate in programs involving such topics as: